Name: NP1
Price: 331.00 USD

- Overview
  - Inhibits activation of the NF-κ B pathway.
    NP1 was identified from a 60 amino acid residue precursor encoded by a 297-bp cDNA sequence from the skin of the amphibian frog Rana limnocharis. NP1 suppresses inflammation by reducing interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) levels, and also up-regulates expression of miR-6328, which in turn down regulates kappa B kinase β (IKKβ). IKKβ reduces phosphorylation of nuclear factor-kappa B p65 (NF- κ B p65) and inhibits NF-κ B (I-κ B), inhibiting activation of the NF-κ B pathway. In middle cerebral artery occlusion/reperfusion (MCAO/R) rats, NP1 reduces the volume of cerebral infarction and relieves neurological dysfunction. NP1 can also significantly alleviate the decrease in viability and increase in apoptosis of neuron like PC12 cells induced by oxygen glucose deprivation/re-oxygenation (OGD/R).
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Neuroprotective Peptide 1
    
    Molecular Formula
    
    C65H108N14O15S2
    
    Molecular Weight
    
    1389.8
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    > 95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Phe-Leu-Pro-Ala-Ala-Ile-Cys*-Leu-Val-Ile-Lys-Thr-Cys*, disulphide bridge between cysteines 7 and 13,FLPAAIC*LVIKTC*
    Modification: Disulphide bridge between cysteines 7 and 13
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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