Name: Octpep-1
Price: 275.00 USD

- Overview
  - Targets PI3K/AKT/mTOR signalling.
    Octpep-1 is a peptide derived from the octopus kaurna, or the southern sand octopus, a species native to the seas around the Great Australian Bight and Tasmania. Octpep-1 disrupts PI3K/AKT/mTOR pathway signalling and selectively reduces the proliferative capacity of human melanoma BRAFV600E mutated cells, with minimal effects on fibroblasts. Octpep-1 has weak agonist activity at tachykinin NK1 receptors but its antiproliferative activity is independent of NK1R expression. Octpep-1 acts synergistically in combination with the mTORC1 inhibitor rapamycin or the ERK1/2 inhibitor LY3214996 to enhance its antiproliferative effects and augment cytotoxicity. Octpep-1 reduces the progression of tumours in vivo, being effective in xenograft mouse melanoma and zebrafish models.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Molecular Formula
    
    C58H86N12O23S
    
    Molecular Weight
    
    1350.56
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >98% by HPLC
    
    Other Properties
    
    Sequence: H-Asp-Pro-Pro-Ser-Asp-Asp-Glu-Phe-Val-Ser-Leu-Met-OH,DPPSDDEFVSLM
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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