Name: Nosiheptide
Price: 225.00 USD

- Overview
  - Nosiheptide is a broad-spectrum bicyclic thiopeptide antibiotic produced by several species of actinomycetes (ie Streptomyces) and was first reported by Japanese researchers in 1970. It has a prolonged post-antibiotic effect in both nosocomial and community-acquired MRSA. Despite its long history in animal health research, Nosiheptide has not been extensively studied.
    Nosiheptide is soluble in ethanol, methanol, DMF and DMSO.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Nosiheptide impacts bacterial protein synthesis in a similar fashion to that of thiostrepton. However unlike thiostrepton, the second macrocyclic ring is linked by relatively fragile lactone and thiolactone bridges to the core cyclic peptide. Nosiheptide inhibits the elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates. This involves pentose-methylation of 23S ribosomal RNA.
    
    Research suggests that the Nosiheptides biosynthetic machinery can lead to engineering novel thiopeptides for drug discovery (Yu et al, 2009).
- Properties
  - CAS Number
    
    56377-79-8
    
    Molecular Formula
    
    C51H43N13O12S6
    
    Molecular Weight
    
    1222.4
    
    Appearance
    
    Yellow solid
    
    Solubility
    
    Soluble in ethanol, methanol, DMF and DMSO
    
    Other Properties
    
    Source: Streptomyces actuosus
    Purity Level: >95% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum, effective for Gram-negative and Gram-positive bacteria. It is also effective against MRSA.