Name: Nisoldipine
Price: 188.00 USD

- Overview
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    Background
    
    Nisoldipine is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
- Properties
  - Categories
    
    calcium channel blocker
    
    Alternative Name
    
    3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
    
    CAS Number
    
    63675-72-9
    
    Molecular Formula
    
    C20H24N2O6
    
    Molecular Weight
    
    388.41
    
    Appearance
    
    A solid
    
    Purity
    
    99.66%
    
    Solubility
    
    insoluble in H2O; ≥10.62 mg/mL in EtOH; ≥11.55 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
    
    * For Research Use Only
- Reference
  - 1. Qianyue Chen, Jiashuo Zheng, et al. "Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock." Eur J Immunol. 2021 May;51(5):1234-1245. PMID:33454984