Noradrenaline bitartrate monohydrate

Please contact us at for specific academic pricing.

Background

Noradrenaline bitartrate monohydrate is an agonist of adrenergic receptors, with Ki values of 330, 56 and 740 nM for α1, α2 and β1 adrenoceptors, respectively [1].
Noradrenaline is a neurotransmitter distributed in both the peripheral and central nervous systems. In the autonomic nervous system, noradrenaline acting at α1-receptors causes constriction of cutaneous blood vessels. In the central nervous system, noradrenaline found primarily in the locus coeruleus in the brainstem, plays important roles in a variety of physiological activities, such as sleep/wake cycles, attention, orientation, mood and memory [2].
In femoral strips isolated from the untreated dogs, noradrenaline bitartrate monohydrate (5 × 10-9 ~ 10-4 M) induced dose-dependent contractions which were inhibited completely by 10-8 M phenoxybcnzamine administered 40 min previously. In the femoral strips isolated from the ephedrine-treated dogs, contractile responses to noradrenaline bitartrate monohydrate were potentiated at low concentrations (5 × 10-9 ~ 10-7 M) but inhibited at high concentrations (5 × 10-7 ~ 10-4 M) [3].

[1]. Ramos B P, Arnsten A F. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacology & Therapeutics, 2007, 113(3): 523-536.
[2]. Bylund D B, Bylund K C. Norepinephrine. Encyclopedia of the Neurological Sciences (Second Edition), 2014, 3: 638–640.
[3]. Furukawa T, Morishita H. Modifications of responses to adrenergic drugs in arterial strip by treatment in vivo with ephedrine and reserpine. The Japanese Journal of Pharmacology, 1975, 25(4): 441-451.