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Overview
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Calcineurin-NFAT interaction inhibitor.
NFAT inhibitor is a high affinity calcineurin binding peptide which acts as a selective inhibitor of the interaction of calcineurin with the transcription factor nuclear factor of activated T cells (NFAT), which it does without affecting calcineurin phosphatase activity or non-NFAT-mediated signalling. Activation of NFAT by calcineurin is a key step in T cell activation and accordingly, NFAT inhibitor peptide blocks NFAT activation and NFAT dependent expression of endogenous T cell cytokine genes. ? Other cytokines that require calcineurin but not NFAT are not affected. NFAT inhibition by NFAT inhibitor peptide is an effective strategy to quench inflammation and hypertrophy.
Please contact us for availability.Please contact us at for specific academic pricing.
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