Name: NF-κB Activation Inhibitor III
Price: 254.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    NF-κB Activation Inhibitor III is a NF-κB inhibitor.NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex controling transcription of DNA, cytokine production as well as cell survival. NF-κB is found in nearly all animal cell types and is involved in cellular responses to stimuli such as cytokines, stress, free radicals, heavy metals, and bacterial or viral antigens.In vitro: Previous study found that NF-κB Activation Inhibitor III could inhibite TNF-a-induced MMP-9 upregulation in concentration-dependently and showed maximal activity at 10 μM. NF-κB Activation Inhibitor III also inhibited TNF-a-induced MMP-9 mRNA transcript accumulation and protein expression. It was also found that NF-κB Activation Inhibitor III strongly inhibited TNF-a-induced NF-jB activity but not AP-1 activity. In addition, NF-κB Activation Inhibitor III was able to strongly inhibit the TNF-a-induced invasion of HT1080 human fibrosarcoma cell line. These findings demonstrated that NF-κB Activation Inhibitor III was a synthetic compound inhibiting TNF-a-induced MMP-9 expression, and therefore NF-κB Activation Inhibitor III would be useful for the development of chemotherapy targeting TNF-a-mediated tumor invasion and metastasis [1]. NF-κB Activation Inhibitor III was used to disrupt NF-κB signaling to evaluate the role of syndecans in mediating extracellular matrix integrity [2].In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, NF-κB Activation Inhibitor III is still in the preclinical development stage.
    
    [1] H. Y. Lee, K. S. Park, M. K. Kim, et al. A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. Biochemical and Biophysical Research Communications 336(2), 716-722 (2005).
    [2] H. Yang, H. Liu, X. Li, et al. TNF-α and TGF-β1 regulate Syndecan-4 expression in nucleus pulposus cells: Role of the mitogen-activated protein kinase and NF-κB pathways. Connect.Tissue Res. 56(4), 281-287 (2015).
- Properties
  - Alternative Name
    
    SM-7368; 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide
    
    CAS Number
    
    380623-76-7
    
    Molecular Formula
    
    C10H5ClN4O5S
    
    Molecular Weight
    
    328.7
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤100mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

NF-κB Activation Inhibitor III

NF-κB Activation Inhibitor III

Background

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