Name: 2,3-Butanedione-2-monoxime
Price: 175.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor.Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain. In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor. Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring. In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially [1].In vivo: So far, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    BDM|Diacetyl Monoxime|NSC 660|NSC 116103; 2,3-butanedione, 2-oxime
    
    CAS Number
    
    57-71-6
    
    Molecular Formula
    
    C4H7NO2
    
    Molecular Weight
    
    101.1
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥5.25 mg/mL in DMSO; ≥60.2 mg/mL in H2O; ≥99.6 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

2,3-Butanedione-2-monoxime

2,3-Butanedione-2-monoxime

Background

We Also Recommend

(S)-SLV 319

JD5037

SW203668