Nafamostat Mesylate(FUT-175)

- Overview
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    Background
    
    Nafamostat mesylate, previously known as FUT-175, is an inhibitor of serine protease that inhibits a variety of serine proteases, including trypsin and several proteases in the coagulation cascade. Although it was originally developed as an inhibitor of complements, Nafamostat mesylate has been widely used for the treatment of inflammation (such as acute pancreatitis) and disseminated intravascular coagulation (DIC). Nafamostat mesylate exhibits extremely potent inhibition against human tryptase as well as tryptase-catalyzed hydrolysis of Boc-Phe-Ser-Arg-MCA with inhibition constant Kivalue of 95.3 pM. Besides its protease-inhibiting activity, nafamostat mesylate, in a recent study, displayed its antimicrobial activity by dose-dependently inhibiting the proliferation of chlamydial in vitro.
- Properties
  - Alternative Name
    
    Nafamostat Mesylate,FUT-175,Futhan; (6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
    
    CAS Number
    
    82956-11-4
    
    Molecular Formula
    
    C19H17N5O2·2CH4O3S
    
    Molecular Weight
    
    539.59
    
    Appearance
    
    A solid
    
    Purity
    
    99.79%
    
    Solubility
    
    ≥27 mg/mL in DMSO; ≥54 mg/mL in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only