PPACK Dihydrochloride

PPACK Dihydrochloride

Catalog Number:
L002368423APE
Mfr. No.:
APE-A2588
Price:
$511
  • Size:
    5mg
    Quantity:
    Add to Cart:
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant Kivalue of 0.24 nM. PPACK covalently binds to the specific active-site Ser of thrombin and cross links with His57 at the binding site forming a tetrahedral PPACK-thrombin complex. The complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. PPACK is currently being investigated as an anti-coagulant to prevent blood coagulation. Study results show that PPACK is able to dose-dependently inhibit thrombin-induced platelet accumulation.

      • Properties
        • Alternative Name
          PPACK Dihydrochloride; N-(2-amino-3-phenylpropanoyl)-1-[1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]pyrrolidine-2-carboxamide
          CAS Number
          142036-63-3
          Molecular Formula
          C21H31ClN6O3·2HCl
          Molecular Weight
          523.88
          Purity
          98.00%
          Solubility
          ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O
          Storage
          Store at -20°C
          SMILES
          C1CC(N(C1)C(CCCN=C(N)N)C(=O)CCl)C(=O)NC(=O)C(CC2=CC=CC=C2)N

          * For Research Use Only

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