PPACK Dihydrochloride

- Overview
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    Background
    
    PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant Kivalue of 0.24 nM. PPACK covalently binds to the specific active-site Ser of thrombin and cross links with His57 at the binding site forming a tetrahedral PPACK-thrombin complex. The complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. PPACK is currently being investigated as an anti-coagulant to prevent blood coagulation. Study results show that PPACK is able to dose-dependently inhibit thrombin-induced platelet accumulation.
- Properties
  - Alternative Name
    
    PPACK Dihydrochloride; N-(2-amino-3-phenylpropanoyl)-1-[1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]pyrrolidine-2-carboxamide
    
    CAS Number
    
    142036-63-3
    
    Molecular Formula
    
    C21H31ClN6O3·2HCl
    
    Molecular Weight
    
    523.88
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only