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Overview
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Predicted MW: Monomer, 8 kDa (70 aa). Macrophage inflammatory protein-3 alpha (MIP-3 alpha), also called CCL20, is expressed in the liver, lungs, lymph nodes, and peripheral blood lymphocytes. MIP-3 alpha expression is strongly induced by inflammatory signals, and downregulated by the anti-inflammatory cytokine interleukin 10 (IL-10). MIP-3 alpha signals through the G protein-coupled receptor CCR6 to function as a chemoattractant to lymphocytes and dendritic cells.
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Overview