MMP Inhibitor II

- Overview
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    Background
    
    MMP Inhibitor II is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 24 nM, 18.4 nM, 30 nM and 2.7 nM for MMP-1, MMP-3, MMP-7 and MMP-9, respectively [1].
    MMPs belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. MMPs have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. These enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. In addition, MMPs exert function in metastasis by promoting tumor invasion and angiogenesis. It was shown that the expression of various members of the MMP family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. Furthermore, MMPs are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1].
    In vitro: Up to now, in vitro study of MMP Inhibitor II is still in the development stage.
    In vivo: Up to now, in vivo study of MMP Inhibitor II is still in the development stage.
- Properties
  - Alternative Name
    
    Matrix Metalloproteinase Inhibitor II,NHDDPC,PG 117025,PGE 4410186; hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-2-pyrimidinecarboxamide
    
    CAS Number
    
    203915-59-7
    
    Molecular Formula
    
    C21H27N3O8S2
    
    Molecular Weight
    
    513.6
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤0.5mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only