Name: MMP 16 (MT3-MMP) catalytic domain
Price: 514.00 USD

- Overview
  - The catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli. Activation of progelatinase A; Degaradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard.
    
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- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    More than 80% of total protein
    
    Formulation
    
    The enzyme is solubilized in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl₂, 1 % glycerin, 0.1 % Triton X-100.
    
    Storage
    
    MT3-MMP is stable until the expiry date given on the label if stored at -70 °C. The enzyme can be kept at -20 °C for several weeks and in ice for 2 days without significant loss of activity. The catalytic domain of MT3-MMP can show a weak autoproteolytic activity at ≥ 30 °C and at concentrations ≥ 0.2 µg/µl. For incubations longer than 1 h it is recommended to dilute the enzyme to ≤ 0.1 µg/µl. Repeated freezing and thawing should be avoided.
    
    Molecular Weight
    
    21 kDa
    
    * For Research Use Only
- Applications
  - Application Description
    
    The recombinant catalytic domain of MT3-MMP is used to study the activation of progelatinase A (matrix metalloproteinase 2) and the degradation of proteins of the extracellular matrix. The enzyme allows screening of matrix metalloproteinase inhibitors and characterization of inhibitor action.

Datasheet

MMP 16 (MT3-MMP) catalytic domain

MMP 16 (MT3-MMP) catalytic domain

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