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ML323

ML323

Catalog Number:
I002097688UBP
Mfr. No.:
F4121
Price:
$592
  • Size:
    25 mg
    Quantity:
    Add to Cart:
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      • Overview

        • ML323 is a cell permealbe, selective and highly potent inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. ML 323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting USP1-UAF1.

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      • Properties
        • Protein Name
          N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
          Source
          Synthetic
          Formulation
          Powder
          Storage
          Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
          Concentration
          N/A
          Molecular Weight
          384.48 Da

          * Research Use Only

    Datasheet
    MSDS

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