Name: ML-031
Price: 282.00 USD

- Overview
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    Background
    
    ML-031 is an agonist of S1P2 with EC50 value of 1 μM [1].
    Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.
    ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay [1].
- Properties
  - Categories
    
    agonist of S1P2
    
    Alternative Name
    
    CID-2113511; 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-2,5-pyrrolidinedione
    
    CAS Number
    
    852230-33-2
    
    Molecular Formula
    
    C19H20N2O3
    
    Molecular Weight
    
    324.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    ≤5mg/ml in ethanol;5mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=CC(C(CN2C(CCC2=O)=O)=O)=C(C)N1CC3=CC=CC=C3
    
    * For Research Use Only