Oleyl Trifluoromethyl Ketone

- Overview
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    Background
    
    Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2]. Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2]. Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].
    
    [1]. Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996 Nov 7;384(6604):83-7.
    [2]. Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.
- Properties
  - Alternative Name
    
    Heptadecyl Trifluoromethyl Ketone,OTK; 1,1,1-trifluoro-10Z-nonadecen-2-one
    
    CAS Number
    
    177987-23-4
    
    Molecular Formula
    
    C19H33F3O
    
    Molecular Weight
    
    334.5
    
    Appearance
    
    A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤25mg/ml in DMSO;25mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Oleyl Trifluoromethyl Ketone

Background

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