Name: MK-2206 dihydrochloride
Price: 292.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    MK-2206 dihydrochloride is a selective inhibitor of Akt1/2/3. MK-2206 inhibites the phosphorylation of Thr308 and Ser 473 of Akt. MK-2206 suppresses Akt signalling pathway and promoting cancer cell death as a single agent as well as in combination with other chemotherapeutic agents. MK-2206 enhance the sensitivity to through apoptosis and enhance the sensitivity to rapamycin via reactive oxygen species. Combination of MK-2206 with etoposide or rapamycin significantly increase antitumor growth effect.
- Properties
  - Alternative Name
    
    MK-2206,MK2206,MK 2206; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one;dihydrochloride
    
    CAS Number
    
    1032350-13-2
    
    Molecular Formula
    
    C25H21N5O·2HCl
    
    Molecular Weight
    
    480.39
    
    Appearance
    
    A solid
    
    Purity
    
    99.64%
    
    Solubility
    
    insoluble in EtOH; ≥12.01 mg/mL in DMSO; ≥2.74 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
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    2. Gulisudumu Maitiabula, Feng Tian, et al. " Liver PP2A-Cα protects from parenteral nutrition-associated hepatic steatosis." Cell Mol Gastroenterol Hepatol. 2022 May 26;S2352-345X(22)00090-X. PMID: 35643235
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MK-2206 dihydrochloride

MK-2206 dihydrochloride

Background

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