Name: Ruxolitinib (INCB018424)
Price: 212.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ruxolitinib dihydrochloride is a specific inhibitor of Janus-associated kinase (JAK1 and JAK2). Ruxolitinib is a small molecular with the formula of C17H21N6O4Pand Molecular Weight of 404. Ruxolitinib phosphate is an administered ATP-competitive cyclopentylpropionitrile derivative and shows inhibition activity on JAK1 and JAK2. Ruxolitinib inhibits phosphorylation of JAK1/2, STAT5, and ERK1/2, resulting in reduced cellular proliferation.
- Properties
  - Alternative Name
    
    Ruxolitinib, INCB018424, INCB-018424; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
    
    CAS Number
    
    941678-49-5
    
    Molecular Formula
    
    C17H18N6
    
    Molecular Weight
    
    306.37
    
    Appearance
    
    A solid
    
    Purity
    
    99.35%
    
    Solubility
    
    insoluble in H2O; ≥15.32 mg/mL in DMSO; ≥17.53 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Lin Du, YolandaWong Ying Yip, et al. "Ruxolitinib Alleviates Uveitis Caused by Salmonella typhimurium Endotoxin." Microorganisms. 2021 Jul 11;9(7):1481. PMID:34361917
    2. Jinqiang Zhang, Hui He, et al. "Priming of microglia with IFN ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects." Glia. 2020 Dec;68(12):2674-2692. PMID:32652855
    3. Gibbs KD, Washington EJ, et al. "The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3." Cell Host Microbe. 2020 Jan 8;27(1):129-139.e4. PMID:31901521
    4. Li L, Shang L, et al. "Janus kinase inhibitor ruxolitinib blocks thymic regeneration after acute thymus injury." Biochem Pharmacol. 2019 Nov 11:113712. PMID:31726048
    5. Hermans MAW, Schrijver B, et al. "The JAK1/JAK2- inhibitor ruxolitinib inhibits mast cell degranulation and cytokine release." Clin Exp Allergy. 2018 Jun 25. PMID:29939445
    6. Zhang S, Li Z, et al. "Interleukin-4 Enhances the Sensitivity of Human Monocytes to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Through Upregulation of Death Receptor 4." J Interferon Cytokine Res. 2018 Apr;38(4):186-194. PMID:29638207
    7. Hall BM, Balan V, et al. "p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli." Aging (Albany NY). 2017 Aug 2;9(8):1867-1884. PMID:28768895
    8. Radhakrishnan H, Ilm K, et al. "MACC1 regulates Fas mediated apoptosis through STAT1/3-Mcl-1 signaling in solid cancers." Cancer Lett. 2017 Jun 23. pii: S0304-3835(17)30402-0. PMID:28649004

Ruxolitinib (INCB018424)

Ruxolitinib (INCB018424)

Background

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