Mithramycin A

Mithramycin A

Catalog Number:
A004364248APE
Mfr. No.:
APE-A4546
Price:
$362
  • Size:
    5mg
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

      • Properties
        • Categories
          Anticancer antibiotic
          Alternative Name
          (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy--D-arabino-hexopyranosyl)--D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl--D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy--D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy--D-arabino-hexo
          CAS Number
          18378-89-7
          Molecular Formula
          C52H76O24
          Molecular Weight
          1085.16
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          Soluble in DMSO
          Storage
          Desiccate at -20°C
          SMILES
          CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

          * For Research Use Only

      • Reference
        • 1. Tang T, Zhu Q, et al. "Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness." Cell Death Dis. 2019 Sep 9;10(9):649. PMID:31501409

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