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Overview
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MAL-dPEG®4-(m-dPEG®12)3, PN 10406, is a thiol-reactive, branched, monodisperse PEG product that can modify the performance and distribution of biologic drugs. This single molecular weight, discrete-length PEG (dPEG®) product consists of a tris core from which branch three methyl-terminated dPEG®12 arms and one maleimide-functionalized dPEG®4 arm. From the reactive site on the maleimido group to the terminal methyl moiety on each of the dPEG®12 branches, the dPEG® spacer is 67 atoms (75.8 Å). This unique branched dPEG® construct increases the water solubility and hydrodynamic volume of conjugates that incorporate it. Also, MAL-dPEG®4-(m-dPEG®12)3 can reduce or eliminate immunogenicity and non-specific, hydrophobic interactions.
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