NHS-dPEG®₄-(m-dPEG®₁₂)₃-ester

NHS-dPEG®4-(m-dPEG®12)3 ester, product number 10401, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. The core of this four-armed discrete PEG (dPEG®) product is tris. Three equal-length dPEG®12 branches terminate with methyl groups. A short dPEG®4 arm ends with an amine-reactive N-hydroxysuccinimidyl (NHS) ester. From the terminal carbonyl carbon of the dPEG®4 arm to each terminal methyl group on the dPEG®12 branches, the distance is 66 atoms (51.1 Å) long. This hydrophilic branched dPEG® product adds hydrodynamic volume to the conjugates, which reduces immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.

PEGylation with dPEG® Products
Conventional PEGylation reagents are disperse polymers. With traditional PEG products, the stated molecular weight represents the average of a Poisson distribution of chain lengths and molecular weights of PEG. Dispersity complicates the analysis of conjugates made with these traditional PEGylation products.

OurdPEG® products have no dispersity. In each product, there is a single, discrete length and molecular weight of the PEG chain. For this reason, we sell our products under the dPEG® tradename. Our dPEG® PEGylation reagents are superior to monodispersed PEG products because our products are synthesized from high-purity starting materials rather than purified out of a polymer mixture.

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