Mag Methyl C Methyl DNA Extraction Magnetic Beads

Our Methyl DNA extraction magnetic beads are specially surface-modified, superparamagnetic, nano-scale microspheres. Their core design principle is based on 5-methylcytosine antibodies or methylated DNA-binding domain proteins, enabling them to specifically recognize and bind methylated fragments within genomic DNA (i.e., fragments where a methyl group is added to the 5th carbon atom of the cytosine in CpG dinucleotides).
Unlike traditional genomic DNA extraction beads (which primarily rely on the non-specific binding of silanol groups to the DNA backbone), methylated DNA extraction magnetic beads are designed to "enrich" methylated fragments from complex whole-genome DNA for subsequent in-depth analysis.


Product Features:
· High Specificity and Affinity: Efficiently enriches methylated DNA, minimizing background interference from unmethylated DNA to the greatest extent.
· ​High Sensitivity: Suitable for methylation analysis of trace samples (e.g., cell biopsies, circulating cell-free DNA).
· No Bisulfite Treatment Required: Compared to methods requiring chemical conversion like whole-genome bisulfite sequencing, MeDIP (Methylated DNA Immunoprecipitation) does not alter the DNA sequence, avoiding associated DNA degradation and biases.
· Simple and Rapid Operation: Features standardized protocols, is easy to use, and suitable for high-throughput sample processing.
· Excellent Compatibility: The enriched DNA can be directly used for various downstream analysis techniques.

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