Superparamagnetic Methylated DNA Extraction Using Magnetic Beads, Mag Methyl B

DNA methylation is a key epigenetic mechanism involving the addition of a methyl group to the fifth carbon of a cytosine base, forming 5-methylcytosine. This modification regulates gene activity without altering the underlying DNA sequence.
Our methylated DNA extraction magnetic beads are specially surface-modified, superparamagnetic, nano-scale microspheres. Their core design principle is based on 5-methylcytosine antibodies or methylated DNA-binding domain proteins, enabling them to specifically recognize and bind methylated fragments within genomic DNA (i.e., fragments where a methyl group is added to the 5th carbon atom of the cytosine in CpG dinucleotides).


Product Features:
· High Specificity & Affinity
Specifically designed to target and bind methylated DNA, ensuring superior enrichment and reducing non-specific carryover.
· Exceptional Sensitivity
Capable of efficiently isolating methylated DNA from limited and challenging samples, including cell-free DNA (cfDNA), FFPE tissues, and low-input samples.
· Maintained DNA Integrity
Provides gentle extraction that preserves DNA strand integrity and methylation status, ensuring reliable results for bisulfite conversion and subsequent analysis.
· Broad Sample Compatibility
Optimized for use with various sample types, including blood, plasma, serum, tissues, and cells.
· Streamlined, Automation-Friendly Workflow
The magnetic beads are compatible with manual protocols and automated high-throughput nucleic acid extraction systems, facilitating a rapid and consistent workflow without the need for organic solvents.
· High Consistency & Reproducibility
Manufactured with uniform size distribution and superior dispersion, guaranteeing batch-to-batch reproducibility and robust experimental performance.

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