m-dPEG®₂-acid

m-dPEG®2-acid, product number 10326, is a very short, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates as a propionic acid group. Also, this product is the precursor to PN10327, m-dPEG®2-NHS ester. Furthermore, m-dPEG®2-acid is part of a broad line of methyl-terminated dPEG® spacers functionalized that range from 2 to 49 ethylene glycol units in length.

This group can be directly coupled to free amines on biomolecules and surfaces using EDC or another carbodiimide. Alternately, the reactive end can be functionalized with N-hydroxysuccinimide (NHS); 2,3,5,6-tetrafluorophenol (TFP); 2,3,4,5,6-pentafluorophenol (PFP); or some other activating agent for reaction with amines.

m-dPEG®2-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules (e.g., peptides and proteins). Coating surfaces or biomolecules with m-dPEG®2-acid can reduce or eliminate non-specific binding and increase hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the trade name dPEG®. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products.

Please contact us at for specific academic pricing.