m-dPEG®₁₂-acid

m-dPEG®12-acid, product number 10328, is a medium-length, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates in a propionic acid group. This product also is the precursor to PN10262, m-dPEG®12-NHS ester and to PN10306, m-dPEG®12-TFP ester. In addition, m-dPEG®12-acid is part of a line of methyl-terminated dPEG® spacers. The dPEG® spacer lengths range from 2 to 49 ethylene glycol units.



The terminal propionic acid moiety can be coupled directly to free amines using EDC or another carbodiimide. Otherwise, the reactive end can be converted into an active ester that can then be conjugated to free amines. N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), and 2,3,4,5,6-pentafluorophenol (PFP) typically are used for this purpose.

m-dPEG®12-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules. In published scientific reports, m-dPEG®12-acid has been used to create optical probes and to study the system pharmacokinetics of poly-L-lysine dendrimers. When used to coat surfaces or modify biomolecules, m-dPEG®12-acid reduces or eliminates non-specific binding and increases water solubility. Please note that modifying the surface amines of biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the dPEG® trade name. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products.

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