m-dPEG®₈-acid

m-dPEG®8-acid, product number 10324, is a medium-length, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates in a propionic acid group. This product is the precursor to PN10260, m-dPEG®8-NHS ester. Moreover, m-dPEG®8-acid is part of a broad line of m-dPEG® spacers with amine-reactive functional groups. Spacer lengths range from 2 to 49 ethylene glycol units.



The terminal propionic acid moiety can be coupled directly to free amines using EDC or another carbodiimide. Alternatively, the reactive end can be functionalized as an active ester that can then be conjugated to free amines. N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), and 2,3,4,5,6-pentafluorophenol (PFP) typically are used for this functionalization.

m-dPEG®8-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®8-acid reduces, and often eliminates, non-specific binding and increases hydrophilicity. Please note that modification of surface amines on biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the dPEG® trade name. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products.

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