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Overview
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Lipoamido-dPEG®₄-acid, product number 10806, is a PEG-based crosslinking and surface modification reagent. The lipoamide moiety rapidly forms stable dative bonds with gold. Using a carbodiimide such as EDC and an acylating agent such N-hydroxysuccinimide (NHS), the propionic acid group will react with free amines to form amide bonds. The water-soluble, non-immunogenic dPEG® spacer adds hydrodynamic volume to conjugates made with this product. The increased hydrodynamic volume reduces the renal clearance of the conjugated molecules.
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Overview
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