Lipoamido-dPEG®₄-TFP ester

Lipoamido-dPEG®4-TFP ester, product number 10641, is a monodispersed PEG crosslinker. From the disulfide bond in the lipoic acid ring to the carbonyl carbon adjacent to the 2,3,5,6-tetrafluorophenol (TFP) ester, the distance is 24 atoms (28.0 Å). The TFP ester forms amide bonds with free amines, while the lipoic acid group forms coordinate covalent (i.e., dative) bonds with metals, especially gold and silver. Applications for this product include creating self-assembled monolayers (SAMs) on metal surfaces and crosslinking and immobilizing peptides and proteins to the surfaces of metal nanoparticles.

Discrete PEG Products
Traditional PEG products are dispersed polymers that contain complex mixtures of different PEG chain lengths and molecular weights in a Poisson distribution. Analysis of conjugates made with these products can be time consuming and expensive.

Quanta BioDesign, Ltd. manufactures and sells monodispersed PEG products under the dPEG® tradename. From our founding, we have pioneered the synthesis of highly pure, monodispersed PEG.

Our dPEG® products are different from traditional PEGylation products. First, all of our products are monodispersed. Each product contains a single PEG product with a discrete chain length and molecular weight. Second, instead of purifying our dPEG® products from a polymer mixture, we synthesize them from highly pure starting materials, building them stepwise until we achieve the desired dPEG® spacer or linker. Our processes are scalable from milligrams to multiple kilograms.

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