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Overview
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Selective neuropeptide Y ?Y1 receptor agonist.
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist with a Ki of 0.39 nM, and also some affinity for Y4 and Y5 receptors. [Leu31,Pro34]-NPY microinjected into the periaqueductal gray produces both analgesic and anxiolytic effects in rats, and intrathecal administration of [Leu31,Pro34]-Neuropeptide Y (human, rat) can attenuate itch behaviour in mice.
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Overview