Lentiviral human STAT6 sgRNA gene knockout kit

Human STAT6

Gene symbol: STAT6
Synonyms: D12S1644 IL-4-STAT STAT6B STAT6C
Species: HUMAN
Gene ID: 6778
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001178078:13:12 NM_003153:13:12 NM_001178079:13:12 NM_001178080:12:10 NM_001178081:11:10