Lentiviral human STAT2 sgRNA gene knockout kit

Human STAT2

Gene symbol: STAT2
Synonyms: IMD44 ISGF-3 P113 STAT113
Species: HUMAN
Gene ID: 6773
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005419:8:7 NM_198332:8:7