Lentiviral human HTR2C sgRNA gene knockout kit

Human HTR2C

Gene symbol: HTR2C
Synonyms: 5-HT1C 5-HT2C 5-HTR2C 5HTR2C HTR1C
Species: HUMAN
Gene ID: 3358
Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001256760:5:2 NM_000868:4:2 NM_001256761:4:2