Name: LAQ824 (NVP-LAQ824,Dacinostat)
Price: 375.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    LAQ824 (also known as NVP-LAQ824 or Dacinostat), a derivative of 4-aminomethylcinnamic hydroxamic acid, is a novel and potent inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC with 50% inhibition concentration IC50 value of 0.03 μM. LAQ824 has been found to inhibit the growth of a variety of cancer cell lines, including colon cancer H1299 and HCT116 cells, breast cancer MDA435 cells, prostate cancer DU145 and PC3 cells and non-small cell lung cancer A549 cells, with IC50 value < 1 μM and induce apoptosis in human breast cancer SKBR-3, BT-474 and MB-468 cells. LAQ824 also dose- and time-dependently inhibits the growth of multiple myeloma cells.
- Properties
  - Alternative Name
    
    LAQ-824, NVP-LAQ 824; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide
    
    CAS Number
    
    404951-53-7
    
    Molecular Formula
    
    C22H25N3O3
    
    Molecular Weight
    
    379.46
    
    Appearance
    
    A solid
    
    Purity
    
    98.06%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Li N, Yang L, et al. "BET bromodomain inhibitor JQ1 preferentially suppresses EBV-positive nasopharyngeal carcinoma cells partially through repressing c-Myc." Cell Death Dis. 2018 Jul 9;9(7):761. PMID:29988031

LAQ824 (NVP-LAQ824,Dacinostat)

LAQ824 (NVP-LAQ824,Dacinostat)

Background

We Also Recommend

AR-42 (OSU-HDAC42)

M344

Scriptaid