Name: AR-42 (OSU-HDAC42)
Price: 277.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AR-42 (also known as OSU-HDAC42), a derivative of hydroxamate-tethered phenylbutyrate, is a novel and potent inhibitor of histone deacetylase (HDAC) that potently inhibits the activity of HDAC with 50% inhibition concentration IC50 value of 16 nM and induces histone H3 acetylation, α-tubulin acetylation and p21 up-regulation, which have been considered as the hallmark indicators of HDAC inhibition. AR-42 has been found to modulate several apoptosis inhibitors as well as cell survival regulator, including Akt, Bcl-xL, Bax, Ku70 and surviving, and exert potent antitumor activity against multiple tumor types, such as human prostate and hepatic cancers, at least partially through PI3K/Akt pathway inhibition.
- Properties
  - Alternative Name
    
    N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide
    
    CAS Number
    
    935881-37-1
    
    Molecular Formula
    
    C18H20N2O3
    
    Molecular Weight
    
    312.36
    
    Purity
    
    99.65%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Bagnall NH, Hines BM, et al. "Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina." Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):51-60. PMID:28110187
    2. Park, Jeenah, et al. "Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy." Epigenomics 7.4 (2015): 641-652. PMID:26111034

AR-42 (OSU-HDAC42)

AR-42 (OSU-HDAC42)

Background

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