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Overview
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Glutathione (GSH) is a prominant non-protein thiol with a concentration of 0.5 – 10 mM in mammalian cells, which serves as an intracellular reducing substance to protect the cells against oxidative stress. Glutathione Peroxidase (GPx) catalyzes the reduction of hydrogen peroxide (H2O2), using reduced GSH, and produces oxidized GSH dimer (GSSG). GSH alsoplays a critical role in many other biological processes, such as protein and DNA synthesis, and amino acids transport as well as protection of cells against oxidation. Considering the fact thatthe potent NFkB inducer TPA increases intracellular GSSG levels and GSSG/GSH ratios, it has been proposed that GSSG might play an important role in the NFkB activating signal cascade.
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