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Overview
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Caffeic Acid Phenethyl Ester (CAPE) or the ester of caffeic acid and phenethyl alcohol is a bioactive component of honeybee hive propolis extract, which hasanti-in flammatory, antitumor, antiviral, antibacterial, antifungal and immunostimulatory activities. It inhibits the activation of nuclear transcription factor NF-κB and suppresses p70S6K and Akt-driven signaling pathways. Moreover, through activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha, CAPE inhibits PDGF-induced proliferation ofvascular smooth muscle cells.
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