Name: KRpep-2d
Price: 274.00 USD

- Overview
  - K-Ras inhibitor.
    KRpep-2d is a potent K-Ras inhibitor, discovered after optimization of an initial hit obtained by phage display technology. KRpep-2d inhibits the enzyme activity of K-Ras(G12D) with an IC50 of 1.6 nM, and with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant in both cell-free enzyme and cell-based assays. Mutated Ras proteins play important roles in cell differentiation, proliferation, and survival of various cancers, and K-Ras(G12D) is considered a very important target as K-Ras mutations underlie 86% of Ras-linked cancers, with 83% of K-Ras mutations being at the G12 residue. KRpep-2d can suppress ERK phosphorylation downstream of K-Ras(G12D) and reduce proliferation in A427 cancer cells.
    
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    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Enzyme Modulators
    
    Alternative Name
    
    K-Ras(G12D)-targeting peptide
    
    Molecular Formula
    
    C109H183N43O25S2
    
    Molecular Weight
    
    2560.02
    
    Purity
    
    >95% by HPLC
    
    Other Properties
    
    Sequence: Ac-Arg-Arg-Arg-Arg-Cys*-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys*-Arg-Arg-Arg-Arg-NH2; disulfide bridge between cysteines 5 and 15,Ac-RRRRC*PLYISYDPVC*RRRR-NH2
    Modification: N terminal is acetylated, C terminal is amidated, disulfide bridge between cysteines 5 and 15
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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