Name: PTD2
Price: 237.00 USD

- Overview
  - WHSC1 inhibitor.
    PTD2 is a peptide derived from the histone H4 sequence surrounding residue K44 (H4K44) that acts as an inhibitor of Wolf-Hirschhorn syndrome candidate 1 (WHSC1). WHSC1 (also known as NSD2 or MMSET) is a histone 3 lysine 36 (H3K36) specific methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3, and is frequently deleted in the genetic disorder Wolf-Hirschhorn syndrome, and has also been implicated as a driver in a variety of haematological and solid tumours. PTD2 inhibits WHSC1 in biochemical and biophysical assays with similar micromolar potencies but demonstrates no enzymatic inhibition against a panel of other histone methyltransferases. PTD2 is a valuable tool for in vitro assay development and validation.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Enzyme Modulators
    
    Molecular Formula
    
    C27H51N9O6
    
    Molecular Weight
    
    597.76
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: Ac-Gly-Val-Nle-Arg-Ile-NH2,Ac-GVXRI-NH2
    Modification: N terminal acetyl, C terminal amide, X = Nle
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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