Name: KJ Pyr 9
Price: 274.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Target: MYCKd value: 6.5 ± 1.0 nMKJ Pyr 9 is a novel small molecule inhibitor of MYC, with the Kd value of 6.5 ± 1.0 nM. Besides, KJ Pyr 9 also suppresses the formation of MYC-MAX and oncogenic transformation induced by MYC in cell culture [1]. In Vitro: In chicken embryo fibroblasts, KJ Pyr 9 was found to have the ability to interfere with the oncogenic activity of MYC, with the best aqueous solubility. Besides, in human B-cell line P493-6, 20 μM KJ Pyr 9 could significantly inhibit cell proliferation, and KJ Pyr 9 could also inhibit the proliferation of NCI-H460, MDA-MB-231, and SUM-159PT cell lines, with the IC50 values between 5-10 μM. Furthermore, treatment of P493-6 cells with KJ Pyr 9 could significantly suppress the transcription ability of MYC [1]. In Vivo: KJ Pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. Besides, in a MDA-MB-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg KJ Pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1]. Clinical trial: No data available recently.
- Properties
  - Alternative Name
    
    4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide
    
    CAS Number
    
    581073-80-5
    
    Molecular Formula
    
    C22H15N3O4
    
    Molecular Weight
    
    385.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤20mg/ml in DMSO;25mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

KJ Pyr 9

KJ Pyr 9

Background

We Also Recommend

Erythromycin A enol ether

Guvacoline (hydrobromide)

L-Phenylephrine