Name: Erythromycin A enol ether
Price: 341.00 USD

- Overview
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    Background
    
    Erythromycin A enol ether, also known as 8,9-anhydroerythromycin A 6,9 hemiketal, is a kind of catabolite of erythromycin A without its antibiotic properties.
    Erythromycin A enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. Erythromycin A enol ether is also the agent of gastrointestinal (GI) distress [1].
    Motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. Motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. Motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. Besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.
    In Vitro: No data available.
    In Vivo: No data available.
    Clinical trial: No data available.
    
    Reference:[1] Steinmetz W E, Shapiro B L, Roberts J J, et al. The structure of erythromycin enol ether as a model for its activity as a motilide.[J]. Journal of Medicinal Chemistry, 2002, 45(22): 4899-4902.
- Properties
  - Categories
    
    β-turn mimic of the peptide hormone motilin
    
    Alternative Name
    
    BRL 46357ER,EM-201; 8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin
    
    CAS Number
    
    33396-29-1
    
    Molecular Formula
    
    C37H65NO12
    
    Molecular Weight
    
    715.9
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤30mg/ml in DMSO;15mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]([H])([[email protected]]2(CC(C)=C([[email protected]@H]([[email protected]]([[email protected]@](C)([[email protected]](O1)CC)O)O)C)O2)C)O[[email protected]]3([[email protected]@H]([[email protected]](C[[email protected]](O3)C)N(C)C)O)[H])C)O[[email protected]@]4(O[[email protected]]([[email protected]@H]([[email protected]@](C)(C4)OC)O)C)[H])C
    
    * For Research Use Only