Name: Kazusamycin B
Price: 523.00 USD

- Overview
  - Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological characteristics. It has anti-cancer properties. This metabolite can inhibit nuclear export and translocation of Rev, a gene product in the HIV-1 genome, at nanomolar concentrations.
    Kazusamycin B is soluble in ethanol and methanol but is practically insoluble in water. It is unstable in DMSO.
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    107140-30-7
    
    Molecular Formula
    
    C32H46O7
    
    Molecular Weight
    
    542.7
    
    Appearance
    
    Colourless Film
    
    Solubility
    
    Soluble in ethanol and methanol. Practically insoluble in water.
    
    Other Properties
    
    Source: Streptomyces spp.
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Active against fungi including S. pombe and R. javanicus. Inactive against Gram-positive and Gram-negative bacteria.
    
    Microbiology Applications: Kazusamycin A and B, along with Leptomycins A and B were isolated from Streptomyces sp. strain A87-18203. These compounds were identified via a screening assay for low MW inhibitors of Rev nuclear transport. They were all found to inhibit the translocation of the regulatory protein Rev at nanomolar concentrations. Rev is need for viral replication of HIV-1 (Wolff et al, 1997).
    
    Eukaryotic Cell Culture Applications: Kazusamycin A has strong cytotoxic activity against HeLa cells in vitro, and when used at 3.3 ng/ml, it prevented cell growth (Umezawa et al, 1984).
    
    Cancer Applications: Kazusamycin B has potent antitumor activity against L1210 cells, arresting the cell cycle at the G1 phase (Takamiya et al, 1988). It also has activity against experimental tumors including murine tumors S180, EL-4, and B16. It had in vitro against doxorubicin-resistant P388 cells (Yoshida et al, 1987). It had cytocidal activity against P388 leukemia cells in vitro (Funaishi et al, 1987).

Datasheet

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