JQ1 (R,S)

JQ1 (R,S)

Catalog Number:
I001528146REA
Mfr. No.:
EI-BRD-002
Price:
$290
  • Size:
    5 mg
    Quantity:
    Add to Cart:
      • Overview
        • (6R,S)-4-(4-Chlorophenyl)-2,3,9-trime?thyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]di?azepine-6-acetic acid 1,1-dimethylethyl ester

          JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer). Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models. Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts. Blocks inflammation and bone loss in periodontitis. Displays reversible contraceptive effects in male mice. Note this product is racemic (+/-) making the IC50 nominally 2 fold greater than literature values for the (+) isomer.

          Please contact us at for specific academic pricing.

      • Properties
        • Molecular Formula
          C23H25ClN4O2S
          Molecular Weight
          MW=457.0
          Appearance
          White powder
          Solubility
          Solubilization: May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)
          Storage
          Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20°C for up to two months.

          * For Research Use Only.

      • Applications
        • Application
          Epigenetic Inhibitors

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