Name: JNJ-26481585
Price: 280.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    JNJ-26481585 is a novel histone deacetylase (HDAC) inhibitor that exerts a strong potency towards class I HDAC (including HDAC1, HDAC2 and HDAC3), with values of inhibition constant IC50 of 0.11, 0.33 and 4.8 nmol/L respectively, leading to strong anti-proliferative activities (IC50 ranging from 3.1 to 246 nmol/L) against a broad range of cancer cell lines including lung, breast, colon, prostate, brain and overian cancer cell lines. Recent study results have shown that JNJ-26481585 strongly induce the HDAC1-suppressed p21waf1,cip1 promoter in vivo, histone H3 acetylation in tumor tissue and apoptosis in human colon cancer cell lines (both APC wild-type and mutant) in vitro.
- Properties
  - Alternative Name
    
    JNJ26481585; N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide
    
    CAS Number
    
    875320-29-9
    
    Molecular Formula
    
    C21H26N6O2
    
    Molecular Weight
    
    394.47
    
    Purity
    
    98.96%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Sauradip Chaudhuri, Martha Fowler, et al. "β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors." ChemRxiv. Mar 27.2020
    2. Zhou H, Mondal A, et al. "Time-Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK-OV3 Ovarian Cancer Cells." Biomed Res Int. 2018 Feb 6;2018:7184253. PMID:29546066
    3. Householder KT, DiPerna DM, et al. "pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma." Colloids Surf B Biointerfaces. 2018 Feb 24;166:37-44. PMID:29533842

JNJ-26481585

JNJ-26481585

Background

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