Ixazomib Citrate

- Overview
  - Ixazomib Citrate is a prodrug of ixazomib, a protease inhibitor used as a second-line treatment of multiple myleoma. When in its biologically active form, ixazomib can inhibit angiogensis and induce apoptosis by activating apoptotic pathways and upregulating tumor-suppressor genes.
    
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    Background
    
    Ixazomib is able to inhibit the chymotrypsin-like proteolytic (β5) site of the 20S proteasome, and at higher concentrations inhibit the caspase-like (β1) and trypsin-like (β2) proteolytic sites.
- Properties
  - CAS Number
    
    1239908-20-3
    
    Molecular Formula
    
    C20H23BCl2N2O9
    
    Molecular Weight
    
    517.12
    
    Appearance
    
    White Powder
    
    Other Properties
    
    Source: Synthetic
    Assay: (HPLC): Not less than 98.0%
    Identification: (NMR): Conforms
    
    Storage
    
    2-8°C
    
    * For research use only