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Overview
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Isovaleryl coenzyme A (Isovaleryl-CoA) is an intermediate in the catabolism of leucine, synthesized from β-methylbutyric acid by acyl-CoA synthetase. It is converted to methylcrotonyl-CoA by isovaleryl-CoA dehydrogenase in the leucine catabolism pathway and by isovaleryl-CoA oxidase in the fatty acid β-oxidation pathway (Kelley et al., 2001; Zhang et al., 2015).
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