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Coenzyme A, Free acid

Coenzyme A, Free acid

Catalog Number:
CAD1547322COE
Mfr. No.:
A-02-10MG/25MG/50MG/100MG
Price:
$231
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      • Overview

        • Coenzyme A (CoA) is a universal metabolic cofactor synthesized from cysteine, pantothenate, and ATP. It is notable for its role in the synthesis and oxidation of fatty acids and the oxidation of pyruvate in the citric acid cycle (Leonardi et al., 2005). All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate (Sibon & Strauss, 2016).

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      • Properties
        • Alternative Name
          Coenzyme A, CoA, CoA-SH, Aluzime, Coalip, Thiol-CoA
          CAS Number
          85-61-0
          Molecular Formula
          C21H36N7O16P3S
          Molecular Weight
          767.53 g/mol
          Appearance
          White to slight yellow
          Formulation
          Lyophilized powder
          Purity
          ≥ 95.0%
          Solubility
          Soluble in water
          Other Properties
          Origin: Biosynthetic
          Stability: ≥ 2 years
          Packaging: PP screw vials
          Storage
          -20°C in a cool and dry place
          Shipping
          Ambient temperature

          * For Research Use Only.

      • Applications
        • Application Description
          Coenzyme A (CoA) Free Acid is widely used in biochemical research and drug development due to its role as a cofactor in numerous enzymatic reactions, particularly in acyl group transfer processes. It is extensively applied in studies of metabolic pathways, such as the citric acid cycle and fatty acid metabolism, to explore enzyme functions, regulatory mechanisms, and potential therapeutic targets (Leonardi et al., 2005). CoA Free Acid is also valuable in drug discovery for evaluating inhibitors or activators of CoA-dependent enzymes, which are crucial for developing treatments for metabolic disorders and infections (Spry et al., 2008).
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    Technical Specification

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