Isavuconazole

- Overview
  - Isavoconazole is an Azol antifungal of the triazole class with broad-spectrum antifungal activity. It was discovered in Kamakura, Japan (Roche). It exhibits antifungal activity against bacteria causing invasive aspergillosis (Aspergillus flavus, Aspergillus fumigatus, and Aspergillus niger). Isavuconazole is also effective against Mucorales such as Rhizopus oryzae, and Mucormycetes.
    
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    Background
    
    Isavuconazole disrupts the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. It inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, that mediates the conversion of lanosterol to ergosterol. Depletion of ergosterol within the fungal cell membrane leads to decreased structural integrity and function of the cell membrane.
- Properties
  - CAS Number
    
    241479-67-4
    
    Molecular Formula
    
    C22H17F2N5OS
    
    Molecular Weight
    
    437.469
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥99%
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: fungi (broad-spectrum)