Epi-Avermectin-B1a

- Overview
  - Epi-Avermectin B1a is the base-catalysed intermediate formed during decomposition of Avermectin B1a in vivo following treatment with Avermectin and is an environmental degradation product. Epi-Avermectin B1a is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analog Delta-2-Avermectin B1a. Epi-Avermectin B1a is very weakly active as a nematocide showing ~100-fold loss of biological activity compared with the parent Avermectin. There are eight Avermectin fractions designated as A1a, A1b, A2a, A2b, B1a, B1b, B2a, and B2b. The B1 fraction has the most effective antiparasitic activity.
    Epi-Avermectin B1a is soluble in ethanol, methanol, DMF and DMSO.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Avermectins can modulate gamma-aminobutyric acid (GABA) chloride channels in vertebrate neurons.
- Properties
  - CAS Number
    
    106434-14-4
    
    Molecular Formula
    
    C48H72O14
    
    Molecular Weight
    
    873.1
    
    Appearance
    
    White solid
    
    Solubility
    
    Soluble in ethanol, methanol, DMF and DMSO
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Insect Biology Applications: Electrophysiological findings by injection of E. elegans mRNA into Xenopus laevis oocytes indicated that Avermectins act on glutamate-gated chloride channels in nematodes.