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Overview
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IL-4 is a pleiotropic cytokine produced by activated T cells. The IL-4 receptor also binds to IL-13, which may contribute many overlapping functions of IL-4 and IL-13. STAT6, a signal transducer and activator of transcription, is important in mediating the immune regulatory signal of this cytokine. This gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. IL-4, IL-13 and IL-5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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