Name: IL-10 (human):Fc (human) (Recombinant) (non-lytic)
Price: Inquiry

- Overview
  - Specific Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggest the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. Other Product Data Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Interleukin-10; Cytokine Sythesis Inhibitory Factor; CSIF
    
    Source
    
    CHO cells
    
    Type
    
    Recombinant Proteins
    
    Reactivity
    
    Human
    
    Purification
    
    >=98% (SDS-PAGE)
    
    Formulation
    
    Reconstitute 10µg vial in 100µl sterile water. Reconstitute 50µg vial in 50µl sterile water. Add 1X PBS to the desired protein concentration. Lyophilized from 0.2µm-filtered solution in PBS.
    
    Storage
    
    Short Term Storage +4°C ; Long Term Storage-20°C ; Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    
    Endotoxin
    
    <0.06EU/μg protein (LAL test; Lonza).
    
    Activity
    
    Shows the biological function of the IL-10 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.
- Applications
  - Application
    
    Functional Assay

IL-10 (human):Fc (human) (Recombinant) (non-lytic)

IL-10 (human):Fc (human) (Recombinant) (non-lytic)

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